Neuronal Oscillations

Ole Jensen

Principal Investigator
Donders Centre for Cognitive Neuroimaging

News:


The research group: Neuronal Oscillations
 

Magnetoencephalography (MEG) and electroencephalography (EEG) allow us to measure brain activity with a high temporal resolution. By applying modern techniques for source modelling it is also possible to estimate which brain regions generate the signals of interest. A major aim of the research group is to apply EEG/MEG in cognitive research to study not only the time course of brain signals, but also relate the signals to the brain regions in which they are produced.

The MEG facility at he F.C. Donders CentreOscillatory brain signals are of particular interest. These oscillations, which are detected by EEG and MEG, are produced by large groups of neurons oscillating in synchrony. Thus, they are bound to play a profound role for processing in the brain. We aim at exploring oscillatory brain activity and its functional role in various cognitive tasks.Her Majesty, the Queen of the Netherlands, inspecting the MEG system during the opening of the F.C. Donders Centre

Our research goals rely on the development and application of modern techniques for signal processing and source modelling. We are implementing tools that will allow us to better characterize various aspects of oscillatory brain activity. For this we apply time-frequency representations of power, measures of synchronization, cross-frequency analysis and source modelling of oscillatory source.

In the quest to bridge the gap between physiology and cognition, we apply computational modelling as well. Networks of physiologically realistic neurons are analysed and simulated on a computer. This approach is aimed at understanding the mechanism responsible for producing oscillations in networks of neurons, and allow us explore the computational advantages of neuronal oscillations.
 
 

Members of the group:



Publications:

Ph.D. Dissertation (May, 1998):

Jensen, O. Oscillatory short-term memory models. Abstract, PDF (19.8 Mb)


Oscillatory Brain Dynamics: modeling, EEG and MEG

van Dijk, H., Nieuwenhuis, I., and Jensen, O. (in press) Left temporal alpha band activity increases during working memory retention of pitches. Eur J Neurosci

Fournier, R., Gussenhoven, C., Jensen, O. and Hagoort, P. (in press) Lateralization
of tonal and intonational pitch processing: An MEG study. Brain Research

van Ede, F. , Jensen, O. , and Maris, E. (in press) Tactile expectation modulates pre-stimulus beta-band oscillations in human sensorimotor cortex. Neuroimage

Bahramisharif, A. , van Gerven, M., Heskes, T. and Jensen, O. (in press) Covert attention allows for continuous control of brain-computer interfaces. Eur J Neurosci

Jensen, O., van Dijk, H., and Mazaheri, A. (in press) Amplitude asymmetry as a mechanism for the generation of slow evoked responses. Commentary. Clin Neurophysiol

Axmacher, A, Henseler, M.M., Jensen, O., Weinreich, I., Elger, C.E. and Fell, J. (2010) Cross-frequency coupling supports multi-item working memory in the human hippocampus. Proceedings of the National Academy of Sciences of the USA

van Dijk, H., Van der Werf, J., Mazaheri, A., Medendorp, W.P., and Jensen, O. (2010) Modulations in oscillatory activity with amplitude asymmetry can produce cognitively relevant event-related responses. Proceedings of the National Academy of Sciences of the USA107:900-905.

de Lange, F.P, Jensen, O., and Dehaene, S. (2010) Accumulation of evidence during sequential decision making: the importance of top-down factors. Journal of Neuroscience 30:731-738.

Van Der Werf, J., Jensen, O., Fries, P., and Medendorp, W.P. (2010) Neuronal synchronization in human posterior parietal cortex during reach planning. Journal of Neuroscience 30:1402-1412.

Haegens, S., Osipova, D., Oostenveld, R., and Jensen, O. (2010)Somatosensory working memory performance depends on both engagement and disengagement of regions in a distributed network. Human Brain Mapping 31:26-35.

Colgin, L.L., Denninger, T., Fyhn, M., Hafting, T., Bonnevie, T., Jensen, O., Moser, M.B., Moser, E.I. (2009) Frequency of gamma oscillations routes flow of information in the hippocampus. Nature 462:353-357.

Takashima, A., Nieuwenhuis, I., Jensen, O., Talamini, L., Rijpkema, M., and Fernandez, G. (2009) Shift from hippocampal to neocortical centered retrieval network with consolidation. Journal of Neuroscience 29:10087-10093.

Van der Werf, J., Buchholz, V., Jensen, O. , and Medendorp W.P. (2009) Neuronal synchronization in human parietal cortex during saccade planning. Behavioural Brain Research 205:329-335.

van Gerven, M., Bahramisharif A., Heskes, T., and Jensen, O. (2009) Selecting features for BCI control based on a covert spatial attention paradigm.  Neural Networks 22:1271-1277.

van Gerven, M., Hesse, C., Jensen, O. and Heskes, T. (2009) Interpreting single trial data using groupwise regularisation. Neuroimage 46:665-676.

Mazaheri, A., Nieuwenhuis, L.C. I, van Dijk, H., and Jensen, O. (2009) Pre-stimulus alpha and mu activity predicts failuire to inhibit motor responses. Human Brain Mapping 30:1791-1800

van Gerven M. and Jensen O. (2009) Attention modulations of posterior alpha as a control signal for two-dimensional brain-computer Interfaces. J Neurosci Methods 179:78-84.

Osipova, D., Hermes, D. and Jensen, O. (2008) Gamma power is phase-locked to posterior alpha activity. PLoS ONE 3(12): e3990 PDF

de Lange, F.P., Jensen, O., Bauer, M., and Toni, I. (2008) Interactions between posterior gamma and frontal alpha/beta oscillations during imagined actions. Front Hum Neurosci 2:7 PDF

van der Werf, J., Jensen, O., Fries, P., and Medendorp, W.P. (2008) Gamma band activity in human posterior parietal cortex encodes the motor goal during delayed pro- and antisaccades. Journal of Neuroscience 28:8397-8405.

Mazaheri, A, and Jensen, O. (2008) Amplitude modulations of brain oscillations generate slow evoked responses. Journal of Neuroscience 28:7781-7787.

Bastiaansen, M. C. M., Mazaheri, A., Jensen O. (2008). Beyond ERPs: oscillatory neuronal dynamics. In: S. Luck, E. Kappenman (Eds): Oxford Handbook of Event-Related Potential Components.  New York, Oxford University Press. In press.

Hesse, C., Heskes, T., and Jensen, O. (2008) Semi-blind identification of movement-related magnetoencephalogram components using a classification approach. Proc 30th Annual Conf IEEE EMBS

Jensen, O., and Hesse, C. (in press) Estimating distributed representations of evoked responses and oscillatory brain activity. In MEG An Introduction to Methods" (edited by Salmelin, Kringleback and Hansen). Oxford University Press

Hagoort, P., Ramsey, N., and Jensen, O., (2008) De gereedschapskist van de cognitieve neurowetenschap. In Het brein to kijk (edited by F. Wijnen and F. Verstraten). Harcourt Book Publishers

Bastiaansen, M.C., Oostenveld, R., Jensen, O. and Hagoort, P. (2008) I see what you mean: theta power increases are involved in the retrieval of lexical semantic information. Brain Lang 106:15-28.

Talamini, L., Nieuwenhuis, I.L.C., Takashima, A., O. Jensen (2008) Sleep directly following learning benefits consolidation of spatial associative memory 15:233-237 Learning and memory

Nieuwenhuis, I.L.C., Takashima, A., Oostenveld, R., Fernandez, G., and O. Jensen (2008) Visual areas become less engaged in associative recall following memory stabilization Neuroimage 40:1319-1327.

van Dijk, H., Schoffelen, J.M., Oostenveld, R., O. Jensen (2008) Pre-stimulus oscillatory activity in the alpha band predicts visual discrimination ability. Journal of Neuroscience 28:1816-1823.

Koelewijn, T., van Schie, H.T., Bekkering, H., Oostenveld, R., and O. Jensen (2008) Motor-cortical beta oscillations are modulated by correctness of observed action Neuroimage 40:767-775.

Jensen, O. and L. L. Colgin (2007) Cross-frequency coupling between neuronal oscillations. Trends in Cognitive Sciences 11:267-269.

Jensen, O., Kaiser, J. and J.P. Lachaux (2007) Human gamma oscillations associated with attention and memory. Trends in Neurosciences 30:317-324 .PDF

Takashima, A., Nieuwenhuis, I., Rijpkema, R., Peterson, K.M., Jensen, O., and Fernandez, G. (2007) Memory trace stabilization leads to large-scale changes in the retrieval network: A functional MRI study on associative memory. Learning and Memory 14:472-472.

van Schie, H. T., Koelewijn, T. Jensen, O. Oostenveld, R., Maris, E., Bekkering, H. (2008) Evidence for fast, low level motor resonance to action observation: An MEG study. Social Neuroscience 3:213-228.

Jokisch, D. and Jensen, O. (2007) Modulation of gamma and alpha activity during a working memory task engaging the dorsal and ventral stream.Journal of Neuroscience 27:3244-3251.  PDF

Medendorp, W.P., Kramer, G.F., Jensen, O., Oostenveld, R., Schoffelen J.M., and Fries, P. (2007) Oscillatory activity in human parietal and occipital cortex shows hemispheric lateralization and memory effects in a delayed double-step saccade task. Cerebral Cortex 17:2364-2374.  PDF

Tuladhar, A.M., ter Huurne, T., Schoffelen, J.M., Maris, E., Oostenveld, R., and Jensen, O., (2007) Parieto-occipital sources account for the increase in alpha activity with working memory load Human Brain Mapping 28:785-792.     DOI

McNaughton, B.L., Battaglia, F.P., Jensen, O., Moser, E.I., and Moser, M. (2006) Path-integration and the neuronal basis of the 'cognitive map. Nature Reviews Neuroscience 7:663-678.   PDF

Osipova, D., Takashima , A., Oostenveld, R., Fernandez, G., Maris, E., and Jensen, O. (2006)Theta and gamma oscillations predict encoding and retrieval of declarative memory. Journal of Neuroscience 26:7523-7531.PDF

Mazaheri, A. and Jensen, O. (2006) Posterior alpha activity is not phase reset by visual stimuli. Proceedings of the National Academy of Sciences of the USA 103:2948-2952.   PDF

Takashima, T., Petersson, K. M., Rutters, F., Tendolkar, I., Jensen, O., Zwarts, M., McNaughton, B., and Fernandez, G. (2006) Declarative memory consolidation in humans: A prospective functional magnetic resonance imaging study. Proceedings of the National Academy of Sciences of the USA 100:2691-2694.  PDF

Jensen, O. (2006) Maintenance of multiple working memory items by temporal segmentation. Neuroscience 139:237-249  DOI

Takashima, A., Jensen, O., Oostenveld, R., Maris, E., van de Coevering, M., and Fernandez, G.(2006) Successful declarative memory formation is associated with ongoing activity during encoding in a distributed neocortical network related to working memory: An MEG study. Neuroscience 139:291-297.DOI

Jensen, O. (2005) Reading the hippocampal code by theta phase locking.Trends in Cognitive Sciences 9:551-553. DOI

Osipova, D., Ahveninen, J., Jensen, O., Ylikoski, A., and Pekkonena, E. (2005) Altered generation of spontaneous oscillations in Alzheimer's disease Neuroimage 27:835-841. PDF

Jensen, O., Goel, P. Kopell, N., Pohja, M., Hari, R., and Ermentrout B. (2005). On the human sensorimotor-cortex rhythm: sources and modeling.Neuroimage 26:347-355. PDF

Liljestrom, M., Kujala, J., Jensen, O., and Salmelin, R. (2005). Neuromagnetic localization of rhythmic activity in the human brain: a comparison of three methods. Neuroimage 25:734-745. PDF

Jensen, O. and Lisman, J.E. (2005). Hippocampal sequence encoding by a multi-item working memory buffer. Trends in Neuroscience 28:67-72.PDF

Jensen, O. (2004), Computing with oscillations by phase encoding and decoding. Proceedings of the International Joint Conference on Neural Networks (IJCNN2004), Budapest PDF

Fries, P., Fernandez, G., and Jensen, O. (2003), When neurons form memories. Trends in Neurosciences 26:123-124. PDF

Simoes S., Jensen, O.,  Parkkonen, L., and Hari, R. (2003) Phase locking between human primary and secondary somatosensory cortices. Proceedings of the National Academy of Sciences of the USA 100:2691-2694. PDF

Jensen, O., Pohja, M., Goel, P., Ermentrout B., and Kopell, N., and Hari, R. (2002) On the physiological basis of the 15-30 Hz motor-cortex rhythm, Proceedings of the 13th International Conference on Biomagnetism,VDE Verlag GMBH, Berlin (Eds. H. Nowak and J. Haueisen and F. Giessler and R. Huonkler),  pp. 313 - 315. PDF

Jensen, O., Gelfand, J., Kounious, K., and Lisman J.E. (2002) Oscillations in the alpha band (9-12 Hz) increase with memory load during retention in a short-term memory task. Cerebral Cortex 12:877-882 , PDF

Jensen, O. and Tesche, C.D. (2002) Frontal theta activity in humans increases with memory load in a working memory task. European Journal of Neuroscience 15:1395-1399 , PDF
NeuroImage, Cover

Jensen, O. and Vanni, S. (2002) A new method to identify multiple sources of oscillatory activty from magnetoencephalographic data. Neuroimage 15:568-574 , PDF

Jensen, O., Kaila, K., and Hari, R. (2002) Visually evoked gamma responses in the human brain are enhanced during voluntary hyperventilation.Neuroimage 15:575-586 , PDF

Jensen. O. (2001) Information transfer between rhythmically coupled networks: reading the hippocampal phase code. Neural Computation 13:2743-2761,Abstract, PDF

Jensen, O. and Lisman J.E. (2001) Dual oscillations as the physiological basis for capacity limits. Behavioral and Brain Sciences 24:126 , PDF

Lisman J.E., Jensen O. and Kahana M (2001) The possible role of an oscillatory short-term memory buffer in long-term memory storage , in Neural Mechanisms of Memory Formation. Ed. C. Holshcer. Cambridge University Press, PDF

Silen, T., Forss, N., Jensen, O., and Hari, R. (2000) Abnormal reactivity of the ~20 Hz motor cortex rhythm in Unverricht-Lundborg progressive myoclonus epilepsy. Neuroimage 12:707-712, PDF

Jensen O. and J.E. Lisman (2000) Position Reconstruction from an Ensemble of Hippocampal Place Cells: Contribution of Theta Phase CodingJournal of Neurophysiology 83:2602-2609. Abstract ,PDF

Jensen O. and J.E. Lisman (1998) An Oscillatory Short-Term Memory Buffer Model Can Account for Data on the Sternberg Task Journal of Neuroscience 18:10688-10699, Abstract , PDF

Jensen O. and J.E. Lisman (1997) The importance of hippocampal gamma oscillations for place cells: A model that accounts for phase precession and spatial shift. in Computational Neuroscience, Trends in Research 1996. Ed. James M. Bower.

Jensen, O., M.A.P. Idiart, and J.E. Lisman (1996) Physiologically realistic formation of autoassociative memory in networks with theta/gamma oscillations: role of fast NMDA channels. Learning and Memory 3:243-256.Abstract, PDF

Jensen, O. and J.E. Lisman (1996) Novel Lists of 7+/-2 Known Items Can Be Reliably Stored in an Oscillatory Short-Term Memory Network: Interaction with Long-Term Memory. Learning and Memory 3:257-263. Abstract, PDF

Jensen, O. and J.E. Lisman (1996) Theta/Gamma Networks with Slow NMDA Channels Learn Sequences and Encode Episodic Memory: role of NMDA channels in recall. Learning and Memory 3:264-278,Abstract, PDF

Jensen, O. and J.E. Lisman (1996) Hippocampal CA3 region predicts memory sequences: accounting for the phase precession of place cells. Learning and Memory 3:279-287, Abstract , PDF
 
 
 

 

Activity dependent regulation of neurons

Some of this work was done in collaboration with Larry Abbott at Brandeis Univeristy.

Papers

Abbott L.F. and O. Jensen (1997) Self-organizing circuits of models neurons. in Computational Neuroscience, Trends in Research 1996. Ed. James M. Bower. Abstract , PDF

Ole Jensen (1995) A Network Model Accounting for Binocular Rivalry Constrained by a Developmental Model for Ocular Dominance and Orientation Columns Outside proposition, Brandeis University., Postscript
 
 

 

Dissipative structures in chemical systems

 
 

This work was done in 1992-1993 in collaboration with Erik Mosekilde and Viggo Ole Pannbacker ( MIDIT-group , Department of Physics at the Technical University of Denmark) and Guy Dewel and Pierre Borckmans ( Center for Nonlinear Phenomena and Complex Systems , Universite Libre de Bruxells).
 
 
 
 

Papers

Jensen, O.,Mosekilde, E., Borckmans, P., and Dewel G. (1996) Computer Simulation of Turing Structures in the Chlorite-Iodide-Malonic Acid System.Physica Scripta. 53:243-251, PDF

Mosekilde E., O. Jensen, G. Dewel and P. Borckmans (1995) Simulation of Turing Patterns in a Chemical Reaction-Diffusion System in Systems Analysis Modelling Simulation 18-19 (A. Sydow Ed., Gordon, 1995) p.45-54,PDF

Jensen O., V.O. Pannbacker, E. Mosekilde, G. Dewel and P. Borckmanns (1995) Turing Structures and Turbulence in Chemical Reaction-Diffusion System. Open Systems and Information Dynamics 3:215-235, PDF

Borckmans, P., O. Jensen, V.O. Pannbacker, E. Mosekilde, G. Dewel & A. De Wit (1995). Localized Turing and Turing-Hopf Patterns. in Modelling the Dynamics of Biological Systems (E. Mosekilde and O.G. Mouritsen Eds, Springer, 1995) p.48-73.

Pannbacker, V. O., Jensen, O., Dewell, G. and Borckmans, P. (1995) Localized Structures in the Chlorine Dioxide-Iodide-Malonic Acid System Proc. NATO ARW on Spatio-Temporal Patterns in Nonequilibrium Complex Systems, Santa Fe Institute, April 13-17, 1993, Addison-Wesley, p. 469-473, PDF

Jensen, O, Pannbacker, V. O., Mosekilde E.,Dewel, G. and Borckmans, P. (1994) Localized structures and front propagation in the Lengyel-Epstein model. Physical Review E, 50:736-749, Abstract, PDF

Jensen, O, Pannbacker, V. O., Mosekilde E.,Dewel, G. and Borckmans, P. (1993) Computer Simulation of Turing Structures in Reaction-Diffusion Systems. Proc. 1st Copenhagen Symposium on Computer Simulation in Biology, Ecology and Medicine, Copenhagen, August 23-25, 103-109.

Jensen, O, Pannbacker, V. O., Dewel, G. and Borckmans, P. (1993) Subcritical transitions to Turing structures. Physics Letters A, 179:91-96, PDF