Shaping functional architecture by oscillatory activity:
gating by inhibition
The main goal
of the 'Neuronal Oscillations' research group is to understand how oscillatory
activity shapes the functional architecture of the working the brain. Our working
hypothesis is that information is gated by inhibiting task-irrelevant regions,
thus routing information to task-relevant regions. The functional inhibition is
reflected in oscillatory activity in the alpha band (8-13 Hz). From a
physiological perspective, the alpha activity provides pulsed inhibition
reducing the processing capabilities of a given area. Active processing in the
engaged areas is reflected by neuronal synchronization in the gamma band (30-100
Hz) accompanied by an alpha band decrease. According to this framework the
brain can be studied as a network by investigating cross-frequency interactions
between gamma and alpha activity. Our main research tool is MEG which allows us
to record oscillatory brain activity from various regions with a sensible
spatial resolution. We address our research questions using attention and
memory tasks. In addition we are using intracranial data and EEG combined with
fMRI recordings and TMS.
Meeuwissen, E.B., Takashima, A., Fernández G. and, Jensen
O. (in press) Increase in posterior alpha activity during rehearsal predicts
successful long-term memory formation of word sequences. Hum Brain Mapp
Mazaheri, A., and Jensen, O. (in press) Rhythmic Pulsing: Linking ongoing brain activity with evoked responses. Front Hum Neurosci
Händel, B.F., Haarmeier, T., and Jensen, O. (in press) Alpha oscillations correlate with the successful inhibition of unattended stimuli. J Cogn Neurosci
van Dijk, H., Nieuwenhuis, I., and Jensen, O. (2010) Left temporal alpha band activity increases during working memory retention of pitches. Eur J Neurosci 31:1701-1707
Fournier, R., Gussenhoven, C., Jensen, O. and Hagoort, P. (2010) Lateralization of tonal and intonational pitch processing: An MEG study. Brain Research 1328:79-88
van Ede, F. , Jensen, O. , and Maris, E. (2010) Tactile expectation modulates pre-stimulus beta-band oscillations in human
sensorimotor cortex. Neuroimage 51:867-876
Bahramisharif, A. , van Gerven, M., Heskes, T. and Jensen, O. (2010) Covert attention allows for continuous control of brain-computer interfaces. Eur J Neurosci 31:1501-1508.
Jensen, O., van Dijk, H., and Mazaheri, A. (2010) Amplitude asymmetry as a mechanism for the generation of slow evoked responses. Commentary. Clin Neurophysiol 121:1148-1149.
Axmacher, A, Henseler, M.M., Jensen, O., Weinreich, I., Elger, C.E. and Fell, J. (2010) Cross-frequency coupling supports multi-item working memory in the human
hippocampus. Proceedings of the National Academy
of Sciences of the USA 107:3228-3233.
van Dijk, H., Van der Werf, J., Mazaheri, A., Medendorp, W.P., and Jensen, O. (2010) Modulations in oscillatory activity with amplitude asymmetry can produce cognitively relevant event-related responses. Proceedings of the National Academy
of Sciences of the USA107:900-905.
de Lange, F.P, Jensen, O., and Dehaene, S. (2010) Accumulation of evidence during sequential decision making: the importance of top-down factors. Journal of Neuroscience 30:731-738.
Van
Der Werf, J., Jensen, O., Fries, P., and Medendorp, W.P. (2010) Neuronal synchronization in human posterior parietal cortex during reach
planning. Journal of Neuroscience 30:1402-1412.
Haegens, S., Osipova, D., Oostenveld, R., and Jensen, O. (2010) Somatosensory working memory performance depends on both engagement and
disengagement of regions in a distributed network. Human Brain Mapping
31:26-35.
Colgin,
L.L., Denninger, T., Fyhn, M., Hafting, T., Bonnevie, T., Jensen, O.,
Moser, M.B., Moser, E.I. (2009) Frequency of gamma oscillations routes flow
of information in the hippocampus. Nature 462:353-357.
Takashima, A., Nieuwenhuis, I., Jensen, O., Talamini, L., Rijpkema, M., and Fernandez, G. (2009) Shift from hippocampal to neocortical centered retrieval network with consolidation. Journal of Neuroscience 29:10087-10093.
Van der Werf, J., Buchholz, V., Jensen, O. , and Medendorp W.P. (2009) Neuronal synchronization in human parietal cortex during saccade planning. Behavioural Brain Research 205:329-335.
van Gerven, M., Bahramisharif A., Heskes, T., and Jensen, O. (2009) Selecting features for BCI control based on a covert spatial attention paradigm. Neural Networks 22:1271-1277.
van Gerven, M., Hesse, C., Jensen, O. and Heskes, T. (2009) Interpreting single trial data using groupwise regularisation. Neuroimage 46:665-676.
Mazaheri, A., Nieuwenhuis, L.C. I, van Dijk, H., and Jensen, O. (2009) Pre-stimulus alpha and mu activity predicts failure to inhibit motor responses. Human Brain Mapping 30:1791-1800
van
Gerven M. and Jensen O. (2009) Attention modulations of posterior
alpha as a control signal for two-dimensional brain-computer Interfaces. J
Neurosci Methods 179:78-84.
Osipova, D., Hermes, D. and Jensen, O. (2008) Gamma power is phase-locked to posterior alpha activity. PLoS ONE 3(12):
e3990 PDF
de Lange, F.P., Jensen, O., Bauer, M., and Toni, I. (2008) Interactions between posterior gamma and frontal alpha/beta oscillations during imagined actions. Front Hum Neurosci 2:7 PDF
van der Werf, J., Jensen, O., Fries, P., and Medendorp, W.P. (2008) Gamma band activity in human posterior parietal cortex encodes the motor
goal during delayed pro- and antisaccades. Journal of Neuroscience 28:8397-8405.
Mazaheri, A, and Jensen, O. (2008) Amplitude modulations of brain
oscillations generate slow evoked responses. Journal of Neuroscience 28:7781-7787.
Bastiaansen,
M. C. M., Mazaheri, A., Jensen O. (2008). Beyond ERPs: oscillatory
neuronal
dynamics. In: S. Luck, E. Kappenman (Eds): Oxford
Handbook of Event-Related Potential Components. New York, Oxford
University Press. In press.
Hesse, C., Heskes, T., and Jensen, O. (2008) Semi-blind identification
of movement-related magnetoencephalogram components using a classification
approach. Proc 30th Annual Conf IEEE EMBS
Jensen, O., and Hesse, C. (in press) Estimating distributed representations
of evoked responses and oscillatory brain activity. In MEG An Introduction
to Methods" (edited by Salmelin, Kringleback and Hansen). Oxford University
Press
Hagoort, P., Ramsey, N., and Jensen, O., (2008) De gereedschapskist
van de cognitieve neurowetenschap. In Het brein to kijk (edited by
F. Wijnen and F. Verstraten). Harcourt Book Publishers
Bastiaansen, M.C., Oostenveld, R., Jensen, O. and Hagoort, P. (2008) I see what you mean: theta power increases are involved in the retrieval
of lexical semantic information. Brain Lang 106:15-28.
Talamini, L., Nieuwenhuis, I.L.C., Takashima, A., O. Jensen (2008) Sleep
directly following learning benefits consolidation of spatial associative
memory 15:233-237 Learning and memory
Nieuwenhuis, I.L.C., Takashima, A., Oostenveld, R., Fernandez, G., and
O. Jensen (2008) Visual areas become less engaged in associative recall
following memory stabilization Neuroimage 40:1319-1327.
van Dijk, H., Schoffelen, J.M., Oostenveld, R., O. Jensen (2008) Pre-stimulus
oscillatory activity in the alpha band predicts visual discrimination ability. Journal of Neuroscience 28:1816-1823.
Koelewijn, T., van Schie, H.T., Bekkering, H., Oostenveld, R., and O.
Jensen (2008) Motor-cortical beta oscillations are modulated by correctness
of observed action Neuroimage 40:767-775.
Jensen, O. and L. L. Colgin (2007) Cross-frequency coupling between
neuronal oscillations. Trends in Cognitive Sciences 11:267-269.
Jensen, O., Kaiser, J. and J.P. Lachaux (2007) Human gamma oscillations
associated with attention and memory. Trends in Neurosciences 30:317-324
.PDF
Takashima, A., Nieuwenhuis, I., Rijpkema, R., Peterson, K.M., Jensen,
O., and Fernandez, G. (2007) Memory trace stabilization leads to large-scale
changes in the retrieval network: A functional MRI study on associative
memory. Learning and Memory 14:472-472.
van Schie, H. T., Koelewijn, T. Jensen, O. Oostenveld, R., Maris, E.,
Bekkering, H. (2008) Evidence for fast, low level motor resonance
to action observation: An MEG study. Social Neuroscience 3:213-228.
Jokisch, D. and Jensen, O. (2007) Modulation of gamma and alpha activity
during a working memory task engaging the dorsal and ventral stream.Journal
of Neuroscience 27:3244-3251. PDF
Medendorp, W.P., Kramer, G.F., Jensen, O., Oostenveld, R., Schoffelen
J.M., and Fries, P. (2007) Oscillatory activity in human parietal and
occipital cortex shows hemispheric lateralization and memory effects in
a delayed double-step saccade task. Cerebral Cortex 17:2364-2374. PDF
Tuladhar, A.M., ter Huurne, T., Schoffelen, J.M., Maris, E., Oostenveld,
R., and Jensen, O., (2007) Parieto-occipital sources account for the
increase in alpha activity with working memory load Human Brain Mapping
28:785-792. DOI
McNaughton, B.L., Battaglia, F.P., Jensen, O., Moser, E.I., and Moser,
M. (2006) Path-integration and the neuronal basis of the 'cognitive
map. Nature Reviews Neuroscience 7:663-678. PDF
Osipova, D., Takashima , A., Oostenveld, R., Fernandez, G., Maris, E.,
and Jensen, O. (2006)Theta and gamma oscillations predict encoding
and retrieval of declarative memory. Journal of Neuroscience 26:7523-7531.PDF
Mazaheri, A. and Jensen, O. (2006) Posterior alpha activity is not
phase reset by visual stimuli. Proceedings of the National Academy
of Sciences of the USA 103:2948-2952. PDF
Takashima, T., Petersson, K. M., Rutters, F., Tendolkar, I., Jensen,
O., Zwarts, M., McNaughton, B., and Fernandez, G. (2006) Declarative
memory consolidation in humans: A prospective functional magnetic resonance
imaging study. Proceedings of the National Academy of Sciences of the
USA 100:2691-2694. PDF
Jensen, O. (2006) Maintenance of multiple working memory items by
temporal segmentation. Neuroscience 139:237-249 DOI
Takashima, A., Jensen, O., Oostenveld, R., Maris, E., van de Coevering,
M., and Fernandez, G.(2006) Successful declarative memory formation
is associated with ongoing activity during encoding in a distributed neocortical
network related to working memory: An MEG study. Neuroscience 139:291-297.DOI
Jensen, O. (2005) Reading the hippocampal code by theta phase locking.Trends in Cognitive Sciences 9:551-553. DOI
Osipova, D., Ahveninen, J., Jensen, O., Ylikoski, A., and Pekkonena,
E. (2005) Altered generation of spontaneous oscillations in Alzheimer's
disease Neuroimage 27:835-841. PDF
Jensen, O., Goel, P. Kopell, N., Pohja, M., Hari, R., and Ermentrout
B. (2005). On the human sensorimotor-cortex rhythm: sources and modeling.Neuroimage 26:347-355. PDF
Liljestrom, M., Kujala, J., Jensen, O., and Salmelin, R. (2005). Neuromagnetic
localization of rhythmic activity in the human brain: a comparison of three
methods. Neuroimage 25:734-745. PDF
Jensen, O. and Lisman, J.E. (2005). Hippocampal sequence encoding
by a multi-item working memory buffer. Trends in Neuroscience 28:67-72.PDF
Jensen, O. (2004), Computing with oscillations by phase encoding
and decoding. Proceedings of the International Joint Conference on
Neural Networks (IJCNN2004), Budapest PDF
Fries, P., Fernandez, G., and Jensen, O. (2003), When neurons form
memories. Trends in Neurosciences 26:123-124. PDF
Simoes S., Jensen, O., Parkkonen, L., and Hari, R. (2003) Phase
locking between human primary and secondary somatosensory cortices. Proceedings
of the National Academy of Sciences of the USA 100:2691-2694. PDF
Jensen, O., Pohja, M., Goel, P., Ermentrout B., and Kopell, N., and
Hari, R. (2002) On the physiological basis of the 15-30 Hz motor-cortex
rhythm, Proceedings of the 13th International Conference on Biomagnetism,VDE
Verlag GMBH, Berlin (Eds. H. Nowak and J. Haueisen and F. Giessler and
R. Huonkler), pp. 313 - 315. PDF
Jensen, O., Gelfand, J., Kounious, K., and Lisman J.E. (2002) Oscillations
in the alpha band (9-12 Hz) increase with memory load during retention
in a short-term memory task. Cerebral Cortex 12:877-882 , PDF
Jensen, O. and Tesche, C.D. (2002) Frontal theta activity in humans
increases with memory load in a working memory task. European Journal
of Neuroscience 15:1395-1399 , PDF
Jensen, O. and Vanni, S. (2002) A new method to identify multiple
sources of oscillatory activty from magnetoencephalographic data. Neuroimage
15:568-574 , PDF
Jensen, O., Kaila, K., and Hari, R. (2002) Visually evoked gamma
responses in the human brain are enhanced during voluntary hyperventilation.Neuroimage
15:575-586 , PDF
Jensen. O. (2001) Information transfer between rhythmically coupled
networks: reading the hippocampal phase code. Neural Computation 13:2743-2761,Abstract, PDF
Jensen, O. and Lisman J.E. (2001) Dual oscillations as the physiological
basis for capacity limits. Behavioral and Brain Sciences 24:126 , PDF
Lisman J.E., Jensen O. and Kahana M (2001) The possible role of an
oscillatory short-term memory buffer in long-term memory storage ,
in Neural Mechanisms of Memory Formation. Ed. C. Holshcer. Cambridge University
Press, PDF
Silen, T., Forss, N., Jensen, O., and Hari, R. (2000) Abnormal reactivity
of the ~20 Hz motor cortex rhythm in Unverricht-Lundborg progressive myoclonus
epilepsy. Neuroimage 12:707-712, PDF
Jensen O. and J.E. Lisman (2000) Position Reconstruction from an
Ensemble of Hippocampal Place Cells: Contribution of Theta Phase CodingJournal
of Neurophysiology 83:2602-2609. Abstract ,PDF
Jensen O. and J.E. Lisman (1998) An Oscillatory Short-Term Memory
Buffer Model Can Account for Data on the Sternberg Task Journal of
Neuroscience 18:10688-10699, Abstract , PDF
Jensen O. and J.E. Lisman (1997) The importance of hippocampal gamma
oscillations for place cells: A model that accounts for phase precession
and spatial shift. in Computational Neuroscience, Trends in Research
1996. Ed. James M. Bower.
Jensen, O., M.A.P. Idiart, and J.E. Lisman (1996) Physiologically
realistic formation of autoassociative memory in networks with theta/gamma
oscillations: role of fast NMDA channels. Learning and Memory 3:243-256.Abstract, PDF
Jensen, O. and J.E. Lisman (1996) Novel Lists of 7+/-2 Known Items
Can Be Reliably Stored in an Oscillatory Short-Term Memory Network: Interaction
with Long-Term Memory. Learning and Memory 3:257-263. Abstract, PDF
Jensen, O. and J.E. Lisman (1996) Theta/Gamma Networks with Slow
NMDA Channels Learn Sequences and Encode Episodic Memory: role of NMDA
channels in recall. Learning and Memory 3:264-278,Abstract, PDF
Jensen, O. and J.E. Lisman (1996) Hippocampal CA3 region predicts
memory sequences: accounting for the phase precession of place cells. Learning
and Memory 3:279-287, Abstract , PDF
Some of this work was done in collaboration with Larry
Abbott at Brandeis Univeristy.
Papers
Abbott L.F. and O. Jensen (1997) Self-organizing circuits of models
neurons. in Computational Neuroscience, Trends in Research 1996. Ed.
James M. Bower. Abstract , PDF
Ole Jensen (1995) A Network Model Accounting for Binocular Rivalry
Constrained by a Developmental Model for Ocular Dominance and Orientation
Columns Outside proposition, Brandeis University., Postscript
Dissipative structures in chemical systems
This work was
done in 1992-1993 in collaboration with Erik Mosekilde and Viggo Ole Pannbacker
( MIDIT-group , Department
of Physics at the Technical University of Denmark) and Guy Dewel and Pierre
Borckmans ( Center
for Nonlinear Phenomena and Complex Systems , Universite Libre de Bruxells).
Papers
Jensen, O.,Mosekilde, E., Borckmans, P., and Dewel G. (1996) Computer
Simulation of Turing Structures in the Chlorite-Iodide-Malonic Acid System.Physica
Scripta. 53:243-251, PDF
Mosekilde E., O. Jensen, G. Dewel and P. Borckmans (1995) Simulation
of Turing Patterns in a Chemical Reaction-Diffusion System in Systems
Analysis Modelling Simulation 18-19 (A. Sydow Ed., Gordon, 1995) p.45-54,PDF
Jensen O., V.O. Pannbacker, E. Mosekilde, G. Dewel and P. Borckmanns
(1995) Turing Structures and Turbulence in Chemical Reaction-Diffusion
System. Open Systems and Information Dynamics 3:215-235, PDF
Borckmans, P., O. Jensen, V.O. Pannbacker, E. Mosekilde, G. Dewel &
A. De Wit (1995). Localized Turing and Turing-Hopf Patterns. in
Modelling the Dynamics of Biological Systems (E. Mosekilde and O.G. Mouritsen
Eds, Springer, 1995) p.48-73.
Pannbacker, V. O., Jensen, O., Dewell, G. and Borckmans, P. (1995) Localized
Structures in the Chlorine Dioxide-Iodide-Malonic Acid System Proc.
NATO ARW on Spatio-Temporal Patterns in Nonequilibrium Complex Systems,
Santa Fe Institute, April 13-17, 1993, Addison-Wesley, p. 469-473, PDF
Jensen, O, Pannbacker, V. O., Mosekilde E.,Dewel, G. and Borckmans,
P. (1994) Localized structures and front propagation in the Lengyel-Epstein
model. Physical Review E, 50:736-749, Abstract, PDF
Jensen, O, Pannbacker, V. O., Mosekilde E.,Dewel, G. and Borckmans,
P. (1993) Computer Simulation of Turing Structures in Reaction-Diffusion
Systems. Proc. 1st Copenhagen Symposium on Computer Simulation in Biology,
Ecology and Medicine, Copenhagen, August 23-25, 103-109.
Jensen, O, Pannbacker, V. O., Dewel, G. and Borckmans, P. (1993) Subcritical
transitions to Turing structures. Physics Letters A, 179:91-96, PDF
This work was
done in 1992-1993 in collaboration with Erik Mosekilde and Viggo Ole Pannbacker
(